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PubMed listing for Titus J Boggon: click here
PubGet listing : click here
Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. Li X*, Zhang R*, Zhang H, He Y, Ji W, Min W, Boggon TJ. Journal of Biological Chemistry. 2010; 285(31):24099-24107 on-line pdf Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity. Petri ET, Ćelić AS, Kennedy SD, Ehrlich BE, Boggon TJ, Hodsdon ME. Proceedings of the National Academy of Sciences. 2010; 107(20):9176-81 on-line pdf |
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Stabilization of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 Is Critical for Vascular Development.
He Y, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W Science Signaling. 3(116), ra26 on-line pdf |
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An asymmetric inter-receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells. Bae JH, Boggon TJ, Tomé F, Mandiyan V, Lax I, Schlessinger, J Proceedings of the National Academy of Sciences. 2010; 107(7):2866-2871 on-line pdf PINCH2 and PINCH1 directly compete to bind the ILK ankyrin repeat domain. Chiswell BP, Stiegler Al, Razinia Z, Boggon TJ, Calderwood DA Journal of Structural Biology. 2010; 70(1):157-163 on-line Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Chen J. Science Signaling. 2009; 2(97):ra73 on-line pdf JAK3: a two-faced player in hematological disorders. Cornejo MG, Boggon TJ, Mercher T. International Journal of Biochemistry and Cell Biology. 2009; 41(12):2376-9. on-line Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2. Casuscelli J*, Schmidt S*, DeGray B, Petri ET, Ćelić A, Folta-Stogniew E, Ehrlich BE, Boggon TJ. Journal of Physiology – Renal Physiology. 2009; 297 (5): F1310-1315 on-line pdf Genetic abnormalities of the EGFR pathway in African-American patients with Non-Small Cell Lung Cancer. Leidner RS, Fu P, Clifford B, Hamdan A, Cheng J, Eisenberg R, Boggon TJ, Skokan M, Franklin WA, Cappuzzo F, Hirsch FR, Varella-Garcia M, Halmos B. Journal of Clinical Oncology. 2009; 27(33):5620-6. on-line pdf FGFR3 associates with and tyrosine-phosphorylates p90RSK2, leading to RSK2 activation that mediates hematopoietic transformation. Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, Lee, BH, Roesel JL, Karsenty G, Hanauer A, Taunton J, Boggon TJ, Gu TL, Chen J. Molecular and Cellular Biology. 2009; 29(8):2105-17. on-line pdf The structural basis of integrin-linked kinase-PINCH interactions. Chiswell BP, Zhang R, Murphy JW, Boggon TJ, Calderwood DA. Proceedings of the National Academy of Sciences. 2008; 105(52):20677-20682 on-line pdf Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity. Tang Z, Jiang S, Du R, Petri ET, El-Telbany A, Chan PS, Kijima T, Dietrich S, Matsui K, Kobayashi M, Sasada S, Okamoto N, Suzuki H, Kawahara K, Iwasaki T, Nakagawa K, Kawase I, Christensen JG, Hirashima T, Halmos B, Salgia R, Boggon TJ, Kern JA, Ma PC. Oncogene. 2008; 28(4):518-33 on-line pdf Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis. Celic A*, Petri ET*, Demeler B, Ehrlich BE, Boggon TJ. Journal of Biological Chemistry. 2008; 283(42):28305-12 on-line pdf The Structure and Clinical Relevance of the EGF Receptor in Human Cancer. Kumar A*, Petri ET*, Halmos B, Boggon TJ. Journal of Clinical Oncology. 2008; 29(10):1742-51. on-line pdf Structural and numerical variation of FLT3/ITD in pediatric AML. Meshinchi S, Stirewalt DL, Alonzo TA, Boggon TJ, Gerbing RB, Rocnik JL, Lange BJ, Gilliland DG, Radich JP. Blood. 2008; 111(10):4930-3. on-line pdf |
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Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles.
Frohling S, Scholl C, Levine RL, Loriaux M, Boggon TJ, Bernard OA, Berger R, Dohner H, Dohner K, Ebert BL, Teckie S, Golub TR, Jiang J, Schittenhelm MM, Lee BH, Griffin JD, Stone RM, Heinrich MC, Deininger MW, Druker BJ, Gilliland DG. Cancer Cell. 2007; 12(6):501-13. on-line pdf |
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Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies. Yu Z, Boggon TJ, Kobayashi S, Jin C, Ma PC, Dowlati A, Kern JA, Tenen DG, Halmos B. Cancer Res. 2007; 67(21):10417-27. on-line pdf BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. Costa DB, Halmos B, Kumar A, Schumer ST, Huberman MS, Boggon TJ, Tenen DG, Kobayashi S. PLoS Med. 2007; 4(10):1669-79. on-line pdf Automated Protein Crystallization Trials using the Thermo Scientific Matrix Hydra II eDrop. Murthy TV, Wang Y, Reynolds C, Boggon TJ. Journal of the Association for Laboratory Automation. 2007; 12(4):213-218. on-line |
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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity. Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ. Cancer Cell. 2007; 11(3):217-27. on-line pdf |
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Activating alleles of JAK3 in acute megakaryoblastic leukemia. Walters DK, Mercher T, Gu TL, O'hare T, Tyner JW, Loriaux M, Goss VL, Lee KA, Eide CA, Wong MJ, Stoffregen EP, McGreevey L, Nardone J, Moore SA, Crispino J, Boggon TJ, Heinrich MC, Deininger MW, Polakiewicz RD, Gilliland DG, Druker BJ. Cancer Cell. 2006; 10(1):65-75. on-line pdf JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model. Mercher T, Wernig G, Moore SA, Levine RL, Gu TL, Frohling S, Cullen D, Polakiewicz RD, Bernard OA, Boggon TJ, Lee BH, Gilliland DG Blood. 2006; 108(8):2770-9. on-line pdf Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Boggon TJ, Li Y, Manley PW, Eck MJ Blood. 2005;106(3):996-1002. on-line pdf Activating mutation in the tyrosine kinase Jak2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, D'Andrea A, Frohling S, Dohner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A, Griffin JD, Eck MJ, Sellers WR, Meyerson M, Golub TR, Lee SJ, Gilliland DG Cancer Cell. 2005;7(4):387-397. on-line pdf |
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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.
Kobayashi S, Boggon TJ, Dayaram T, Janne PA, Kocher O, Meyerson M, Johnson BE, Eck MJ, Tenen DG, Halmos B N Engl J Med. 2005;352(8):786-92. on-line pdf |
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Structure and regulation of Src family kinases. Boggon TJ, Eck MJ Oncogene. 2004;23(48):7918-27. on-line pdf Identification and characterization of a novel activating mutation of the FLT3 tyrosine kinase in AML. Jiang J, Paez JG, Lee JC, Bo R, Stone RM, DeAngelo DJ, Galinsky I, Wolpin BM, Jonasova A, Herman P, Fox EA, Boggon TJ, Eck MJ, Weisberg E, Griffin JD, Gilliland DG, Meyerson M, Sellers WR Blood. 2004;104(6):1855-8. on-line pdf |
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EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M Science. 2004;304(5676):1497-500. on-line pdf |
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Apocrustacyanin C1 crystals grown in space and on earth using vapour-diffusion geometry: protein structure refinements and electron-density map comparisons Habash J, Boggon TJ, Raftery J, Chayen NE, Zagalsky PF, Helliwell JR Acta Crystallogr D Biol Crystallogr. 2003;59(7):1117-23. on-line pdf C-Cadherin ectodomain structure and implications for cell adhesion mechanisms Boggon TJ, Murray J, Chappuis-Flament S, Wong E, Gumbiner BM, Shapiro L Science. 2002;296(5571):1308-13. on-line pdf PDB Molecule of the month: March 2008 pdf G-Protein Signaling Through Tubby Proteins Santagata S, Boggon TJ, Baird CL, Gomez CA, Zhao J, Shan WS, Myszka DG, Shapiro L Science. 2001;292(5524):2041-50. on-line pdf Screening for phasing atoms in protein crystallography. Boggon TJ, Shapiro L Structure. 2000;8:R143-R149. on-line pdf Synchrotron X-ray reciprocal-space mapping, topography and diffraction resolution studies of macromolecular crystal quality. Boggon TJ, Helliwell JR, Judge RA, Olczak A, Siddons DP, Snell EH, Stojanoff V Acta Crystallogr D Biol Crystallogr. 2000;56(7):868-80. on-line pdf Implication of tubby proteins as transcription factors by structure-based functional analysis. Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L Science. 1999;286(5447):2119-25. on-line pdf Purification, crystallization and initial X-ray analysis of the C1 subunit of the astaxanthin protein, V600, of the chondrophore Velella velella. Chayen NE, Boggon TJ, Raftery J, Helliwell JR, Zagalsky PF Acta Crystallogr D Biol Crystallogr. 1999;55(1):266-8. on-line pdf Bound-solvent structures for microgravity-, ground control-, gel- and microbatch-grown hen egg-white lysozyme crystals at 1.8 Å resolution. Dong J, Boggon TJ, Chayen NE, Raftery J, Bi RC, Helliwell JR Acta Crystallogr D Biol Crystallogr. 1999;55(4):745-52. on-line pdf Protein crystal movements and fluid flows during microgravity growth. Boggon TJ, Chayen NE, Snell EH, Dong J, Lautenschlager P, Potthast L, Siddons DP, Stojanoff V, Gordon E, Thompson AW, Zagalsky PF, Bi RC, Helliwell JR Phil. Trans. R. Soc. Lond. A. 1998;356(1739):1045-61. abstract Partial improvement of crystal quality for microgravity grown apocrustacyanin C1. Snell EH, Cassetta A, Helliwell JR, Boggon TJ, Weckert E, Holzer K, Schroer K, Gordon EJ, Zagalsky PF Acta Crystallogr D Biol Crystallogr. 1997;53:231-9. synopsis CCD video observation of microgravity crystallization of lysozyme and correlation with accelerometer data. Snell EH, Boggon TJ, Helliwell JR, Moskowitz ME, Nadarajah A Acta Crystallogr D Biol Crystallogr. 1997;53:747-55. synopsis Lysozyme crystal growth kinetics monitored using a Mach-Zehnder interferometer. Snell EH, Helliwell JR, Boggon TJ, Lautenschlager P, Potthast L Acta Crystallogr D Biol Crystallogr. 1996;52:529-33. synopsis Trends and challenges in experimental macromolecular crystallography. Chayen NE, Boggon TJ, Cassetta A, Deacon A, Gleichmann T, Habash J, Harrop SJ, Helliwell JR, Nieh YP, Peterson MR, Raftery J, Snell EH, Hadener A, Niemann AC, Siddons DP, Stojanoff V, Thompson AW, Ursby T, Wulff M Q Rev Biophys. 1996;29(3):227-78. synopsis |
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The crystal structure analysis of d(CGCGAASSCGCG)2, a synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides.
Boggon TJ, Hancox EL, McAuley-Hecht KE, Connolly BA, Hunter WN, Brown T, Walker RT, Leonard GA Nucleic Acids Res. 1996;24(5):951-61. on-line pdf |
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