PubMed listing for Titus J Boggon: click here Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis. Ćelić A*, Petri ET*, Demeler B, Ehrlich BE, Boggon TJ. Journal of Biological Chemistry 2008; 283(42):28305-12 on-line   pdf The Structure and Clinical Relevance of the EGF Receptor in Human Cancer. Kumar A*, Petri ET*, Halmos B, Boggon TJ. Journal of Clinical Oncology 2008; 29(10):1742-51. on-line   pdf Structural and numerical variation of FLT3/ITD in pediatric AML. Meshinchi S, Stirewalt DL, Alonzo TA, Boggon TJ, Gerbing RB, Rocnik JL, Lange BJ, Gilliland DG, Radich JP. Blood 2008; 111(10):4930-3. on-line    pdf

Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles. Fröhling S, Scholl C, Levine RL, Loriaux M, Boggon TJ, Bernard OA, Berger R, Döhner H, Döhner K, Ebert BL, Teckie S, Golub TR, Jiang J, Schittenhelm MM, Lee BH, Griffin JD, Stone RM, Heinrich MC, Deininger MW, Druker BJ, Gilliland DG. Cancer Cell. 2007; 12(6):501-13. on-line    pdf

Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies. Yu Z, Boggon TJ, Kobayashi S, Jin C, Ma PC, Dowlati A, Kern JA, Tenen DG, Halmos B. Cancer Res. 2007; 67(21):10417-27. on-line    pdf BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. Costa DB, Halmos B, Kumar A, Schumer ST, Huberman MS, Boggon TJ, Tenen DG, Kobayashi S. PLoS Med. 2007; 4(10):1669-79. on-line    pdf Automated Protein Crystallization Trials using the Thermo Scientific Matrix Hydra II eDrop. Murthy TV, Wang Y, Reynolds C, Boggon TJ. Journal of the Association for Laboratory Automation. 2007; 12(4):213-218. on-line

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity. Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ. Cancer Cell. 2007; 11(3):217-27. on-line    pdf

Activating alleles of JAK3 in acute megakaryoblastic leukemia. Walters DK, Mercher T, Gu TL, O'hare T, Tyner JW, Loriaux M, Goss VL, Lee KA, Eide CA, Wong MJ, Stoffregen EP, McGreevey L, Nardone J, Moore SA, Crispino J, Boggon TJ, Heinrich MC, Deininger MW, Polakiewicz RD, Gilliland DG, Druker BJ. Cancer Cell. 2006; 10(1):65-75. on-line    pdf JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model. Mercher T, Wernig G, Moore SA, Levine RL, Gu TL, Frohling S, Cullen D, Polakiewicz RD, Bernard OA, Boggon TJ, Lee BH, Gilliland DG Blood. 2006; 108(8):2770-9. on-line    pdf Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Boggon TJ, Li Y, Manley PW, Eck MJ Blood. 2005;106(3):996-1002. on-line    pdf Activating mutation in the tyrosine kinase Jak2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, D'Andrea A, Frohling S, Dohner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A, Griffin JD, Eck MJ, Sellers WR, Meyerson M, Golub TR, Lee SJ, Gilliland DG Cancer Cell. 2005;7(4):387-397. on-line    pdf

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. Kobayashi S, Boggon TJ, Dayaram T, Janne PA, Kocher O, Meyerson M, Johnson BE, Eck MJ, Tenen DG, Halmos B N Engl J Med. 2005;352(8):786-92. on-line    pdf

Structure and regulation of Src family kinases. Boggon TJ, Eck MJ Oncogene. 2004;23(48):7918-27. on-line    pdf Identification and characterization of a novel activating mutation of the FLT3 tyrosine kinase in AML. Jiang J, Paez JG, Lee JC, Bo R, Stone RM, DeAngelo DJ, Galinsky I, Wolpin BM, Jonasova A, Herman P, Fox EA, Boggon TJ, Eck MJ, Weisberg E, Griffin JD, Gilliland DG, Meyerson M, Sellers WR Blood. 2004;104(6):1855-8. on-line    pdf

EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M Science. 2004;304(5676):1497-500. on-line  pdf

Apocrustacyanin C1 crystals grown in space and on earth using vapour-diffusion geometry: protein structure refinements and electron-density map comparisons Habash J, Boggon TJ, Raftery J, Chayen NE, Zagalsky PF, Helliwell JR Acta Crystallogr D Biol Crystallogr. 2003;59(7):1117-23. on-line    pdf C-Cadherin ectodomain structure and implications for cell adhesion mechanisms Boggon TJ, Murray J, Chappuis-Flament S, Wong E, Gumbiner BM, Shapiro L Science. 2002;296(5571):1308-13. on-line    pdf   PDB Molecule of the month: March 2008  pdf G-Protein Signaling Through Tubby Proteins Santagata S, Boggon TJ, Baird CL, Gomez CA, Zhao J, Shan WS, Myszka DG, Shapiro L Science. 2001;292(5524):2041-50. on-line    pdf Screening for phasing atoms in protein crystallography. Boggon TJ, Shapiro L Structure. 2000;8:R143-R149. on-line    pdf Synchrotron X-ray reciprocal-space mapping, topography and diffraction resolution studies of macromolecular crystal quality. Boggon TJ, Helliwell JR, Judge RA, Olczak A, Siddons DP, Snell EH, Stojanoff V Acta Crystallogr D Biol Crystallogr. 2000;56(7):868-80. on-line    pdf Implication of tubby proteins as transcription factors by structure-based functional analysis. Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L Science. 1999;286(5447):2119-25. on-line    pdf Purification, crystallization and initial X-ray analysis of the C1 subunit of the astaxanthin protein, V600, of the chondrophore Velella velella. Chayen NE, Boggon TJ, Raftery J, Helliwell JR, Zagalsky PF Acta Crystallogr D Biol Crystallogr. 1999;55(1):266-8. on-line    pdf Bound-solvent structures for microgravity-, ground control-, gel- and microbatch-grown hen egg-white lysozyme crystals at 1.8 Å resolution. Dong J, Boggon TJ, Chayen NE, Raftery J, Bi RC, Helliwell JR Acta Crystallogr D Biol Crystallogr. 1999;55(4):745-52. on-line    pdf Protein crystal movements and fluid flows during microgravity growth. Boggon TJ, Chayen NE, Snell EH, Dong J, Lautenschlager P, Potthast L, Siddons DP, Stojanoff V, Gordon E, Thompson AW, Zagalsky PF, Bi RC, Helliwell JR Phil. Trans. R. Soc. Lond. A. 1998;356(1739):1045-61. abstract Partial improvement of crystal quality for microgravity grown apocrustacyanin C1. Snell EH, Cassetta A, Helliwell JR, Boggon TJ, Weckert E, Holzer K, Schroer K, Gordon EJ, Zagalsky PF Acta Crystallogr D Biol Crystallogr. 1997;53:231-9. synopsis CCD video observation of microgravity crystallization of lysozyme and correlation with accelerometer data. Snell EH, Boggon TJ, Helliwell JR, Moskowitz ME, Nadarajah A Acta Crystallogr D Biol Crystallogr. 1997;53:747-55. synopsis Lysozyme crystal growth kinetics monitored using a Mach-Zehnder interferometer. Snell EH, Helliwell JR, Boggon TJ, Lautenschlager P, Potthast L Acta Crystallogr D Biol Crystallogr. 1996;52:529-33. synopsis Trends and challenges in experimental macromolecular crystallography. Chayen NE, Boggon TJ, Cassetta A, Deacon A, Gleichmann T, Habash J, Harrop SJ, Helliwell JR, Nieh YP, Peterson MR, Raftery J, Snell EH, Hadener A, Niemann AC, Siddons DP, Stojanoff V, Thompson AW, Ursby T, Wulff M Q Rev Biophys. 1996;29(3):227-78. synopsis

The crystal structure analysis of d(CGCGAASSCGCG)2, a synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides. Boggon TJ, Hancox EL, McAuley-Hecht KE, Connolly BA, Hunter WN, Brown T, Walker RT, Leonard GA Nucleic Acids Res. 1996;24(5):951-61. on-line    pdf