Our Structures — Boggon Lab

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Our Structures

c-Src SH3 bound to nickel

Calicdan et al., 2025
PDB code 9OFX
SHP2 tandem SH2 domains with PZR doubly tyrosine phosphorylated ITIM peptide

Perla et al., 2025
PDB code 9MQ5
C2-GAP region of RasGAP (p120RasGAP, RASA1)

Paul, Chen et al., 2025
PDB code 9BZ4
Autoregulation of the LIM kinases by their PDZ domain

Casanova-Sepúlveda et al., 2023
PDB code 8GI4
Diverse RasGAP interactions with a range of doubly phosphorylated partners

Vish et al., 2023
SDSBDB codes SASDRJ6, SASDRK6, SASDRL6, SASDRE6, SASDRF6, SASDRG6, SASDRH6
RasGAP SH2-SH3-SH2 region with doubly phosphorylated p190RhoGAP

Stiegler et al., 2022
PDB code 8DGQ
SASBDB codes SASDPM4 SASDPN4
PAK4 recognition of integrin β5

Ha et al., 2022
PDB codes 7S46 7S47 7S48
DLC1 GAP domain with p120RasGAP SH3 domain

Chau et al., 2022
PDB code 7TPB
PAK4 recognition of physiological substrates

Chetty et al., 2020
PDB codes 6WLX 6WLY
FLVR-unique SH2 domain

Jaber Chehayeb et al., 2020
PDB codes 6WAX 6WAY
p120RasGAP N-SH2 with p190RhoGAP phosphopeptide

Jaber Chehayeb et al., 2019
PDB codes 6PXB 6PXC
N-terminal pseudoGTPase domain of p190RhoGAP

Stiegler and Boggon. 2018
PDB code 6D4G
CDC42 with PAK4

Ha and Boggon. 2018
PDB codes 5UPK 5UPL
PEAK1 (Sugen Kinase 269) pseudokinase

Ha and Boggon. 2018
PDB code 6BHC
PAK4 crystal structures suggest unusual kinase conformational movements

Zhang, et al., 2018
PDB codes 5VED 5VEE 5VEF
p190RhoGAP proteins contain pseudoGTPase domains

Stiegler and Boggon. 2017
PDB codes 5U4U 5U4V
LIMK1 recognition of cofilin

Hamill et al., 2016
PDB codes 5HVK 5HVJ
KRIT1 ARD-FERM

Zhang et al., 2015
PDB code 5D68
MEKK3 PB1 domain in complex with CCM2 HHD domain

Fisher, Deng, Liu et al., 2015
PDB code 4Y5O
CCM3 recognition of CCM2 LD motif

Draheim, Li et al., 2015
PDB code 4TVQ
ABL2/ARG kinase with Dasatinib

Ha et al., 2015
PDB code 4XLI
CCM2 PTB domain in complex with KRIT1

Fisher et al., 2015
PDB code 4WJ7
SNX17 FERM domain with KRIT1 peptide

Stiegler et al., 2014
PDB code 4TKN
Abl SH2

Gifford, Liu et al., 2014
PDB code 4EIH
DFG+1 Ser/Thr kinase specificity

Chen, Ha et al., 2014
PDB codes 4JDH 4JDI 4JDJ 4JDK
PAK6 substrate and inhibitor specificity

Gao et al., 2013
PDB codes 4KS7 4KS8
ICAP1 and KRIT1 peptide

Liu and Boggon. 2013
PDB code 4JIF
SHP1 apo and phosphate bound

Alicea-Velazquez and Boggon. 2013
PDB codes 4HJP 4HJQ
SAXS analysis of the Integrin Linked Kinase, PINCH, parvin (IPP) heterotrimeric complex

Stiegler et al. 2013
KRIT1 with ICAP1

Liu, Draheim et al., 2013
PDB codes 4DX8 4DX9
SHP-1/JAK1 interaction

Alicea-Velazquez et al., 2013
PDB codes 4GRY 4GRZ 4GS0
RAC1-P29S is a spontaneously activating cancer-associated GTPase

Davis MJ, et al., 2013
PDB codes 4GZL 4GZM
CCM2 Harmonin Homology Domain

Fisher OS, et al., 2013
PDB code 4FQN
PAK4 pseudosubstrate regulation

Ha BH, et al., 2012
PDB codes 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ
Beta-parvin binding to paxillin

Stiegler AL, et al., 2012
PDB codes 4EDL 4EDM 4EDN
KRIT1 FERM with Rap1

Li X, et al., 2012
PDB code 4DXA
SAXS for polycystin-2

Celic AS, Petri ET et al., 2012
Lysozyme contamination in a cortactin-Arg-lysozyme complex

Liu W et al., 2012
PDB code 3ULR
CCM3 recognition of paxillin LD motifs

Li X et al., 2011
PDB codes 3RQE 3RQF 3RQG
CCM3/PDCD10

Li X and Zhang R et al., 2010
PDB codes 3L8I 3L8J
NMR structure of the EF-hand domain of polycystin-2

Petri ET et al., 2010
PDB code 2KQ6
PINCH2 with ILK ARD

Chiswell BP et al., 2010
PDB code 3IXE
Integrin-linked kinase ARD with PINCH1 LIM1 domain

Chiswell BP et al., 2008
PDB code 3F6Q
Jak3 kinase domain

Boggon TJ et al., 2005
PDB code 1YVJ
Extracellular C-Cadherin

Boggon TJ et al., 2002
PDB code 1L3W
G-protein signaling by tubby proteins

Santagata et al., 2001
PDB codes 1I7E
Calcium bound Adiponectin

PDB code 1C3H
Apocrustacyanin C1 crystals grown in space

Habash J et al., 2003
PDB codes 1OBQ 1OBU
Tubby

Boggon et al., 1999
PDB codes 1C8Z
Lysozyme crystals grown in space, earth, gel and microbatch

Dong J et al., 1999
PDB codes 1BVX 1BWH 1BWI 1BWJ
d(CGCGAASSCGCG)2, synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides

Boggon TJ et al., 1996
PDB code 233D

c-Src SH3 bound to nickel

SHP2 tandem SH2 domains with PZR doubly tyrosine phosphorylated ITIM peptide

C2-GAP region of RasGAP (p120RasGAP, RASA1)

Autoregulation of the LIM kinases by their PDZ domain

Diverse RasGAP interactions with a range of doubly phosphorylated partners

RasGAP SH2-SH3-SH2 region with doubly phosphorylated p190RhoGAP

PAK4 recognition of integrin β5

DLC1 GAP domain with p120RasGAP SH3 domain

PAK4 recognition of physiological substrates

FLVR-unique SH2 domain

p120RasGAP N-SH2 with p190RhoGAP phosphopeptide

N-terminal pseudoGTPase domain of p190RhoGAP

CDC42 with PAK4

PEAK1 (Sugen Kinase 269) pseudokinase

PAK4 crystal structures suggest unusual kinase conformational movements

p190RhoGAP proteins contain pseudoGTPase domains

LIMK1 recognition of cofilin

KRIT1 ARD-FERM

MEKK3 PB1 domain in complex with CCM2 HHD domain

CCM3 recognition of CCM2 LD motif

ABL2/ARG kinase with Dasatinib

CCM2 PTB domain in complex with KRIT1

SNX17 FERM domain with KRIT1 peptide

Abl SH2

DFG+1 Ser/Thr kinase specificity

PAK6 substrate and inhibitor specificity

ICAP1 and KRIT1 peptide

SHP1 apo and phosphate bound

SAXS analysis of the Integrin Linked Kinase, PINCH, parvin (IPP) heterotrimeric complex

KRIT1 with ICAP1

SHP-1/JAK1 interaction

RAC1-P29S is a spontaneously activating cancer-associated GTPase

CCM2 Harmonin Homology Domain

PAK4 pseudosubstrate regulation

Beta-parvin binding to paxillin

KRIT1 FERM with Rap1

SAXS for polycystin-2

Lysozyme contamination in a cortactin-Arg-lysozyme complex

CCM3 recognition of paxillin LD motifs

CCM3/PDCD10

NMR structure of the EF-hand domain of polycystin-2

PINCH2 with ILK ARD

Integrin-linked kinase ARD with PINCH1 LIM1 domain

Jak3 kinase domain

Extracellular C-Cadherin

G-protein signaling by tubby proteins

Calcium bound Adiponectin

Apocrustacyanin C1 crystals grown in space

Tubby

Lysozyme crystals grown in space, earth, gel and microbatch

d(CGCGAASSCGCG)2, synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides